Tying replication to cell identity
نویسندگان
چکیده
منابع مشابه
Replication Timing: A Fingerprint for Cell Identity and Pluripotency
Many types of epigenetic profiling have been used to classify stem cells, stages of cellular differentiation, and cancer subtypes. Existing methods focus on local chromatin features such as DNA methylation and histone modifications that require extensive analysis for genome-wide coverage. Replication timing has emerged as a highly stable cell type-specific epigenetic feature that is regulated a...
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ژورنال
عنوان ژورنال: Nature Reviews Molecular Cell Biology
سال: 2013
ISSN: 1471-0072,1471-0080
DOI: 10.1038/nrm3593